The Journal of Physiology, Band 48

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Cambridge University Press, 1914
 

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Seite 430 - ... be in a good condition. It is evident from what we have said above that the word tone is properly employed as synonymous with physiological condition or fitness of the muscle fibre, and its measure is the energy set free per unit length of muscle fibre at each contraction of the heart. A good heart, ie one with a good tone, will carry on a large circulation against a high arterial pressure and nearly empty itself at each contraction, while a heart with a defective tone, as is the case when it...
Seite 396 - Application was made to the Government Grant Committee of the Royal Society for a grant of £250 for the hire of a vessel.
Seite 428 - The law of the heart is therefore the same as that of skeletal muscle, namely, that the mechanical energy set free on passage from the resting to the contracted state depends on the area of « chemically active surfaces », ie, on the length of the muscle fibres.
Seite 133 - More recently (1914) Dixon and Halliburton (9), in the course of an extensive study of the cerebro-spinal fluid, have come to the conclusion "that the cranial contents cannot any longer be regarded as a fixed quantity without the power of expanding or contracting in volume." It must be assumed, however, that with certain reservations, the data favor the idea of a relatively fixed total volume of the cranial contents but with the capacity for change in any one of the three chief elements concerned....
Seite 133 - ... influenced passively to a small extent by changes in the arterial and venous pressures but such alterations are insignificant compared with the independent changes in pressure which occur as the result of secretory activity.
Seite 430 - ... condition, ie, one with a good tone, will carry on a large circulation against a high arterial pressure and nearly empty itself at each contraction, while a heart with a defective tone, as is the case when it is tired, can carry on the same circulation but only when its fibers at the beginning of each contraction are much longer, ie, when the heart is dilated. In the latter case the output of blood will be the same as in the former but both the systolic and the diastolic volumes of the heart...
Seite 473 - In somewhat larger doses (0.01 to 1 mgm.) it causes also pronounced vaguslike inhibition of the heart, and various other effects of stimulating nerves of the cranial and sacral divisions of the autonomic system — secretion of saliva, contraction of the oesophagus, stomach and intestine, and of the urinary bladder.
Seite 334 - The output of the heart is equal to and determined by the amount of blood flowing into the heart, and may be increased or diminished within very wide limits according to the inflow.
Seite 461 - ... no constant connection is found between the diastolic pressure in the heart's cavities, ie, the initial tension on the muscle fibres, and the contraction of the heart, though as a rule these two quantities will be altered together; but in every case there is a direct proportion between the diastolic volume of the heart, ie, the length of its muscle fibres, and the energy set free in the following systole. The law of the heart is therefore the same as that of skeletal muscle, namely, that the...
Seite 429 - The output of the heart is a function of its filling, the energy of its contraction depends on the state of dilatation of the heart's cavities.

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